Plasmalogen Therapeutics

 

Med-Life Discoveries is a clinical-stage biopharma company developing novel plasmalogen-based therapeutics for the treatment of Rhizomelic Chondrodysplasia Punctata (RCDP) and other neurological conditions*

*MLD’s plasmalogen therapeutics are currently undergoing required formal regulatory safety and efficacy studies and are not currently available to the public.

News

Catch up on our latest whereabouts and milestones here!

News
RhizoKids 2025
RhizoKids 2025
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Q&A: Approved drugs versus supplements
Q&A: Approved drugs versus supplements
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MLD announces publication of RhizoQOL survey
MLD announces publication of RhizoQOL survey
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First human safety and pharmacokinetic study of a plasmalogen augmentation therapy published by MLD
First human safety and pharmacokinetic study of a plasmalogen augmentation therapy published by MLD
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MLD announces plans for Rare Disease Day 2025
MLD announces plans for Rare Disease Day 2025
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MLD attending CORD Conference 2024
MLD attending CORD Conference 2024
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MLD to present at World Orphan Drug Congress Europe
MLD to present at World Orphan Drug Congress Europe
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MLD publishes world's first chronic plasmalogen-deficient Alzheimer's mouse model
MLD publishes world's first chronic plasmalogen-deficient Alzheimer's mouse model
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Patient-Focused Drug Development Session
Patient-Focused Drug Development Session
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MLD attending World Orphan Drug Congress 2024
MLD attending World Orphan Drug Congress 2024
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Rare Disease Day 2024 Coloring Contest Rules
Rare Disease Day 2024 Coloring Contest Rules
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MLD Presenting at AD/PD Conference
MLD Presenting at AD/PD Conference
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MLD Announces Completion of Dosing with Plasmalogen-precursor PPI-1011 in its Phase I Clinical Trial
MLD Announces Completion of Dosing with Plasmalogen-precursor PPI-1011 in its Phase I Clinical Trial
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Multiple ascending dose study of PPI-1011 begins dosing
Multiple ascending dose study of PPI-1011 begins dosing
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MLD to attend Canadian Conference on Dementia
MLD to attend Canadian Conference on Dementia
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SASKATOON-BASED BIOPHARMA COMPANY MED-LIFE DISCOVERIES RECEIVES NO OBJECTION LETTER FROM HEALTH CANADA TO BEGIN A HEALTHY ADULT PHASE 1 TRIAL FOR PPI-1011
SASKATOON-BASED BIOPHARMA COMPANY MED-LIFE DISCOVERIES RECEIVES NO OBJECTION LETTER FROM HEALTH CANADA TO BEGIN A HEALTHY ADULT PHASE 1 TRIAL FOR PPI-1011
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MLD attending Rhizokids International Conference in Alabama
MLD attending Rhizokids International Conference in Alabama
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MLD attending International Plasmalogen Conference
MLD attending International Plasmalogen Conference
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MLD attending BioPharm America
MLD attending BioPharm America
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MLD attending World Orphan Drug Congress 2022
MLD attending World Orphan Drug Congress 2022
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MLD presenting at AAIC 2022
MLD presenting at AAIC 2022
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MLD's newest manuscript describes the metabolism and tissue distribution of PPI-1011
MLD's newest manuscript describes the metabolism and tissue distribution of PPI-1011
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MLD on location in Wilmington Delaware
MLD on location in Wilmington Delaware
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MLD Obtains Analytical Cannabis License from Health Canada
MLD Obtains Analytical Cannabis License from Health Canada
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World Alzheimer's Day 2021
World Alzheimer's Day 2021
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MLD's latest publication estimating the prevalence and incidence of RCDP
MLD's latest publication estimating the prevalence and incidence of RCDP
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MLD announces new collaboration with Dr. Marie-Eve Tremblay at the University of Victoria
MLD announces new collaboration with Dr. Marie-Eve Tremblay at the University of Victoria
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Rare Disease Day 2021
Rare Disease Day 2021
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Research Collaboration with Montreal Heart Institute Research Center
Research Collaboration with Montreal Heart Institute Research Center
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MLD attending World Orphan Drug Congress
MLD attending World Orphan Drug Congress
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Peroxisomal Disorders

Rhizomelic Chondrodysplasia Punctata (RCDP) affects fewer than 100 patients in North America. But there is #hopeforRCDP and other plasmalogen-deficient peroxisomal disorders with PPI-1011: a first-in-class plasmalogen therapy in clinical development.

 
 

Neurological Conditions

Plasmalogen deficiency is associated with several neurological conditions including Alzheimer’s disease, Parkinson’s disease, and Multiple sclerosis. Therapeutically augmenting plasmalogens represents a new paradigm for the management of these diseases.

 
 
Literature
Role and function of peroxisomes in neuroinflammation
Role and function of peroxisomes in neuroinflammation
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Determination of plasmalogen molecular species in hen eggs
Determination of plasmalogen molecular species in hen eggs
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Setting the curve: the biophysical properties of lipids in mitochondrial form and function
Setting the curve: the biophysical properties of lipids in mitochondrial form and function
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Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy.
Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy.
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Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease
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Sea cucumber plasmalogen regulates the lipid profile in high-fat diet mouse liver via lipophagy.
Sea cucumber plasmalogen regulates the lipid profile in high-fat diet mouse liver via lipophagy.
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Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet.
Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet.
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Plasmalogens and octanoylcarnitine serve as early warnings for central retinal artery occlusion.
Plasmalogens and octanoylcarnitine serve as early warnings for central retinal artery occlusion.
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Tissue-specific roles of peroxisomes revealed by expression meta-analysis.
Tissue-specific roles of peroxisomes revealed by expression meta-analysis.
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Simultaneous intake of chlorella and ascidian ethanolamine plasmalogen accelerates activation of BDNF-TrkB-CREB signaling in rats.
Simultaneous intake of chlorella and ascidian ethanolamine plasmalogen accelerates activation of BDNF-TrkB-CREB signaling in rats.
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Lipidomic analysis reveals differences in the extent of remyelination in the brain and spinal cord.
Lipidomic analysis reveals differences in the extent of remyelination in the brain and spinal cord.
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100th Blog
100th Blog
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1-O-alkyl-glycerols from squid Berryteuthis magister reduce inflammation and modify fatty acid and plasmalogen metabolism in asthma associated with obesity
1-O-alkyl-glycerols from squid Berryteuthis magister reduce inflammation and modify fatty acid and plasmalogen metabolism in asthma associated with obesity
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Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism
Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism
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Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5.
Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5.
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Antioxidative stress metabolic pathways in moderately active individuals.
Antioxidative stress metabolic pathways in moderately active individuals.
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Plasmalogen profiling in porcine brain tissues by LC-MS/MS
Plasmalogen profiling in porcine brain tissues by LC-MS/MS
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Lipidomic signature of stroke recurrence after transient ischemic attack.
Lipidomic signature of stroke recurrence after transient ischemic attack.
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Plasmalogen improves memory function by regulating neurogenesis in a mouse model of Alzheimer’s diseases.
Plasmalogen improves memory function by regulating neurogenesis in a mouse model of Alzheimer’s diseases.
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The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis.
The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis.
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Molecular and biophysical features of hippocampal “lipid rafts aging” are modified by dietary n-3 long-chain polyunsaturated fatty acids.
Molecular and biophysical features of hippocampal “lipid rafts aging” are modified by dietary n-3 long-chain polyunsaturated fatty acids.
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Neonatal rhizomelic chondrodysplasia punctata type 2 caused by a novel homozygous variant in the GNPAT gene.
Neonatal rhizomelic chondrodysplasia punctata type 2 caused by a novel homozygous variant in the GNPAT gene.
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Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis.
Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis.
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Increased n-6 polyunsaturated fatty acids indicate pro- and anti-inflammatory lipid modifications in synovial membranes with rheumatoid arthritis.
Increased n-6 polyunsaturated fatty acids indicate pro- and anti-inflammatory lipid modifications in synovial membranes with rheumatoid arthritis.
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Ether lipid-mediated antioxidant defense in Alzheimer’s disease.
Ether lipid-mediated antioxidant defense in Alzheimer’s disease.
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An Introduction to Plasmalogens in Honor of RCDP Awareness Day 2023
An Introduction to Plasmalogens in Honor of RCDP Awareness Day 2023
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Protective properties of marine alkyl glycerol ethers in chronic stress.
Protective properties of marine alkyl glycerol ethers in chronic stress.
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Reduction of ether-type glycerophospholipids, plasmalogens, by NF-ĸB signal leading to microglial activation.
Reduction of ether-type glycerophospholipids, plasmalogens, by NF-ĸB signal leading to microglial activation.
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Regulation of plasmalogen biosynthesis in mammalian cells and tissues.
Regulation of plasmalogen biosynthesis in mammalian cells and tissues.
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Overlapping and distinct features of cardiac pathology in inherited human and murine ether lipid deficiency.
Overlapping and distinct features of cardiac pathology in inherited human and murine ether lipid deficiency.
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Literature

Relevant literature, curated by our own scientific communications team