https://med-life.ca/literature daily 0.75 2026-01-26 https://med-life.ca/literature/2025/12/19/the-lipidome-of-the-lateral-ventricle-choroid-plexus-exhibits-sex-specific-changes-across-aging monthly 0.5 2026-01-26 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1768940199790-H64G6SJIC6I9VORVZQLO/GettyImages-1182137375.jpg Literature - The lipidome of the lateral ventricle choroid plexus exhibits sex-specific changes across aging - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2025/12/9/multi-omic-analysis-reveals-lipid-dysregulation-associated-with-mitochondrial-dysfunction-in-parkinsons-disease-brain monthly 0.5 2025-12-09 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1765294375328-YAMJEQ6UTPE0U7H2B72C/GettyImages-1301086444.jpg Literature - Multi-omic analysis reveals lipid dysregulation associated with mitochondrial dysfunction in Parkinson’s disease brain. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2025/10/6/184qtg8hbdsta2434mc91lk5jt16xl monthly 0.5 2025-10-09 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1759865477749-6PAGDBGTMLYX1Z16AR2A/GettyImages-1181981782.jpg Literature - Bifunctional probes reveal the rules of intracellular ether lipid transport - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2025/9/10/brain-region-specific-lipid-dysregulation-in-ldopa-induced-dyskinesia-in-a-primate-model-of-parkinsons-disease-y7jwr-ldkhw monthly 0.5 2025-09-10 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1757519708815-ZLNSL0AKMX2GCK6YWWNO/unsplash-image-9gj40P4jU0A.jpg Literature - Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson’s disease - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2025/2/3/role-and-function-of-peroxisomes-in-neuroinflammation monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1738605032570-MITI0BMN7OMP1FLH4698/GettyImages-1206314365.jpg Literature - Role and function of peroxisomes in neuroinflammation - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/12/9/uig2u4weeme38d34n7bze3catqwvzh monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1733761755284-5YOAFZDONFUOBT3VDG22/unsplash-image-leOh1CzRZVQ.jpg Literature - Determination of plasmalogen molecular species in hen eggs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/9/26/setting-the-curve-the-biophysical-properties-of-lipids-in-mitochondrial-form-and-function monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1727360703439-455WOVFZ8R200I7FF0FQ/image-asset.jpeg Literature - Setting the curve: the biophysical properties of lipids in mitochondrial form and function - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/8/21/tafazzin-deficiency-causes-substantial-remodeling-in-the-lipidome-of-a-mouse-model-of-barth-syndrome-cardiomyopathy monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1724274709785-7DHT8CP3KDNR8A4BUX4I/GettyImages-843281640.jpg Literature - Tafazzin deficiency causes substantial remodeling in the lipidome of a mouse model of Barth Syndrome cardiomyopathy. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/7/19/sex-differences-in-lipidomic-and-bile-acid-plasma-profiles-in-patients-with-and-without-coronary-artery-disease monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1721832723427-EF0M29RYL9YU5IHL1WXW/GettyImages-610988158.jpg Literature - Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/6/19/sea-cucumber-plasmalogen-regulates-the-lipid-profile-in-high-fat-diet-mouse-liver-via-lipophagy monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1718827750821-TAVH9IUGIIRL62B5KDVX/GettyImages-1182137375.jpg Literature - Sea cucumber plasmalogen regulates the lipid profile in high-fat diet mouse liver via lipophagy. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/5/16/sea-cucumber-plasmalogen-enhance-lipophagy-to-alleviate-abnormal-lipid-accumulation-induced-by-high-fat-diet monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1716394325457-FQ6E4Y5TZUTG6FM9CKI1/GettyImages-1404861184.jpg Literature - Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet. - Make it stand out Image of an orange-footed sea cucumber (Cucumaria frondosa). https://med-life.ca/literature/2024/4/17/plasmalogens-and-octanoylcarnitine-serve-as-early-warnings-for-central-retinal-artery-occlusion monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1713387492001-IUSFHE3XL3R21NTQIAE1/GettyImages-181060289.jpg Literature - Plasmalogens and octanoylcarnitine serve as early warnings for central retinal artery occlusion. - Make it stand out Image of a retina. https://med-life.ca/literature/2024/3/25/tissue-specific-roles-of-peroxisomes-revealed-by-expression-meta-analysis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1711386618452-41D7PUA3NKA6RSCEHIQM/GettyImages-516727646.jpg Literature - Tissue-specific roles of peroxisomes revealed by expression meta-analysis. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/2/8/simultaneous-intake-of-chlorella-and-ascidian-ethanolamine-plasmalogen-accelerates-activation-of-bdnf-trkb-creb-signaling-in-rats monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1707420791179-4ONNYC4QATYINN8ECSJ7/GettyImages-1144879039.jpg Literature - Simultaneous intake of chlorella and ascidian ethanolamine plasmalogen accelerates activation of BDNF-TrkB-CREB signaling in rats. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2024/1/12/lipidomic-analysis-reveals-differences-in-the-extent-of-remyelination-in-the-brain-and-spinal-cord monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1705347482934-RV06BFI6O83EEC71LAHJ/GettyImages-503536036.jpg Literature - Lipidomic analysis reveals differences in the extent of remyelination in the brain and spinal cord. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/12/5/gjimcyadgy3e5z6md0npdsrcv2u0u5 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/84717728-5a1e-4606-a298-47dccc7689d2/Image.png Literature - 100th Blog - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/11/21/1-o-alkyl-glycerols-from-squid-berryteuthis-magister-reduce-inflammation-and-modify-fatty-acid-and-plasmalogen-metabolism-in-asthma-associated-with-obesity monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1700603702577-YD4EL5A8ZT4S0KX1X9US/GettyImages-524386430.jpg Literature - 1-O-alkyl-glycerols from squid Berryteuthis magister reduce inflammation and modify fatty acid and plasmalogen metabolism in asthma associated with obesity - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/11/6/niclosamide-as-a-chemical-probe-for-analyzing-sars-cov-2-modulation-of-host-cell-lipid-metabolism monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1699302571967-DLKK8QV3O7FIKGY2EXZ4/image-asset.jpeg Literature - Niclosamide as a chemical probe for analyzing SARS-CoV-2 modulation of host cell lipid metabolism - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/10/18/normal-plasmalogen-levels-are-maintained-in-tissues-from-mice-with-hepatocyte-specific-deletion-in-peroxin-5 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1698247074724-49M26T381B9ZD88S7GQE/GettyImages-860040064.jpg Literature - Normal plasmalogen levels are maintained in tissues from mice with hepatocyte-specific deletion in peroxin 5. - Make it stand out Image of stained human hepatocyte culture. https://med-life.ca/literature/2023/10/5/antioxidative-stress-metabolic-pathways-in-moderately-active-individuals monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1697037551197-HXX1YDHX5BOBHX4NG7T1/image-asset.jpeg Literature - Antioxidative stress metabolic pathways in moderately active individuals. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/ca6477e8-d632-4b4c-ad19-d2b80430e6b9/Picture1.png Literature - Antioxidative stress metabolic pathways in moderately active individuals. - Make it stand out Figure 1: A score plot from the OPLS-DA model comparing active vs sedentary participants showing the class-discriminatory component 1 (x-axis) versus 1 Orthogonal component 1 (y-axis) (A) and the corresponding loadings plot from the OPLS-DA model showing metabolites that belong to significantly enriched pathways (B) https://med-life.ca/literature/2023/9/25/plasmalogen-profiling-in-porcine-brain-tissues-by-lc-msms monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1695739899629-9A53Q17KK7KKOSW273MG/GettyImages-622291636.jpg Literature - Plasmalogen profiling in porcine brain tissues by LC-MS/MS - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/47c92858-bb3a-429d-9314-b40e7f86da31/Scheme+1.png Literature - Plasmalogen profiling in porcine brain tissues by LC-MS/MS - Make it stand out Scheme 1. The workflow of producing the porcine brain products, including the raw products (No. 1 and No. 2) and the glycerophospholipid products (No. 3–No. 8). https://med-life.ca/literature/2023/9/7/lipidomic-signature-of-stroke-recurrence-after-transient-ischemic-attack monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/2e500deb-c083-42d6-ad89-bf1e321fdee1/Picture1.jpg Literature - Lipidomic signature of stroke recurrence after transient ischemic attack. - Make it stand out CT scan of a brain after ischemic stroke. https://med-life.ca/literature/2023/8/22/plasmalogen-improves-memory-function-by-regulating-neurogenesis-in-a-mouse-model-of-alzheimers-diseases monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/823c4d12-97b8-45f6-84c0-40abb3afde89/Picture1.jpg Literature - Plasmalogen improves memory function by regulating neurogenesis in a mouse model of Alzheimer’s diseases. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/8/14/the-origin-of-long-chain-fatty-acids-required-for-de-novo-ether-lipidplasmalogen-synthesis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1692045706967-9R10L8TTM3VSU4PM3I5U/GettyImages-1181981782.jpg Literature - The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/7/26/molecular-and-biophysical-features-of-hippocampal-lipid-rafts-aging-are-modified-by-dietary-n-3-long-chain-polyunsaturated-fatty-acids monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/25c4fefa-c08c-491c-b381-18ceefc56d4e/Lipid%2Braft%2Bimage.jpg Literature - Molecular and biophysical features of hippocampal “lipid rafts aging” are modified by dietary n-3 long-chain polyunsaturated fatty acids. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/6/29/neonatal-rhizomelic-chondrodysplasia-punctata-type-2-caused-by-a-novel-homozygous-variant-in-the-gnpat-gene monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/6ce7fd92-2109-4eb1-80d5-b14363353565/Figure+1.png Literature - Neonatal rhizomelic chondrodysplasia punctata type 2 caused by a novel homozygous variant in the GNPAT gene. - Make it stand out Upper limbs radiographs show rhizomelic shortening of both humeri, flared metaphyses, and stippled calcifications of proximal and distal epiphyses. https://med-life.ca/literature/2023/6/29/several-serum-lipid-metabolites-are-associated-with-relapse-risk-in-pediatric-onset-multiple-sclerosis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/22abb33c-8785-496f-83bd-b2459ba0acae/image-asset.jpeg Literature - Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis. - Make it stand out The image contains two neurons, one with intact myelin sheath along its axon (bottom) and one with demyelination occurring (top) https://med-life.ca/literature/2023/6/19/increased-n-6-polyunsaturated-fatty-acids-indicate-pro-and-anti-inflammatory-lipid-modifications-in-synovial-membranes-with-rheumatoid-arthritis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1687202487972-RV3SONYDAK89X1EPN2DZ/GettyImages-1156927812.jpg Literature - Increased n-6 polyunsaturated fatty acids indicate pro- and anti-inflammatory lipid modifications in synovial membranes with rheumatoid arthritis. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/5/29/ether-lipid-mediated-antioxidant-defense-in-alzheimers-disease monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1685977821776-P74OWWM6IMFTJ90R96HE/GettyImages-1328467745.jpg Literature - Ether lipid-mediated antioxidant defense in Alzheimer’s disease. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/5/17/an-introduction-to-plasmalogens-in-honor-of-rcdp-day-2023 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1595514021390-D8AYRNQYYR8J73TBEEOD/Plasmalogen.png Literature - An Introduction to Plasmalogens in Honor of RCDP Awareness Day 2023 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/5/4/protective-properties-of-marine-alkyl-glycerol-ethers-in-chronic-stress monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1683565127455-INBRT25G9W47GRIOIRON/GettyImages-1048931142.jpg Literature - Protective properties of marine alkyl glycerol ethers in chronic stress. - Make it stand out A lymphocyte surrounded by red blood cells. https://med-life.ca/literature/2023/4/10/reduction-of-ether-type-glycerophospholipids-plasmalogens-by-nf-b-signal-leading-to-microglial-activation monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1682365820253-UIMC3UQB11BLTDCR5EIM/GettyImages-1356994730.jpg Literature - Reduction of ether-type glycerophospholipids, plasmalogens, by NF-ĸB signal leading to microglial activation. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/3/20/regulation-of-plasmalogen-biosynthesis-in-mammalian-cells-and-tissues monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/28fccc99-9ad9-477a-8a8c-4d45d072fab6/Picture1.jpg Literature - Regulation of plasmalogen biosynthesis in mammalian cells and tissues. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/3/21/overlapping-and-distinct-features-of-cardiac-pathology-in-inherited-human-and-murine-ether-lipid-deficiency monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1679679773835-0WOQKZ0Z1PNAIC00XFYT/GettyImages-1217258922.jpg Literature - Overlapping and distinct features of cardiac pathology in inherited human and murine ether lipid deficiency. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/2/15/-synuclein-and-lipids-in-erythrocytes-of-gaucher-disease-carriers-and-patients-before-and-after-enzyme-replacement-therapy monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1677533624534-LB0NNQIRNF87P3JLHM1M/GettyImages-956478224.jpg Literature - α-synuclein and lipids in erythrocytes of Gaucher disease carriers and patients before and after enzyme replacement therapy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/2/15/alterations-in-ether-lipid-metabolism-and-the-consequences-for-the-mouse-lipidome monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1677533590504-GRLL6XEX5C1JXOTECR0V/GettyImages-1093086594.jpg Literature - Alterations in ether lipid metabolism and the consequences for the mouse lipidome. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/1/19/genetic-defects-in-peroxisome-morphogenesis-pex11-dlp1-and-nme3-affect-dha-phospholipid-metabolism monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1676474031082-78KYHE65LT7LUJI0I0LY/GettyImages-1302770617.jpg Literature - Genetic defects in peroxisome morphogenesis (Pex11β, DLP1, and NME3) affect DHA-phospholipid metabolism. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2023/1/11/transient-ca2-entry-by-plasmalogen-mediated-activation-of-receptor-potential-cation-channel-promotes-ampk-activity monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1673970224769-KICH5JZBFH4TR71V766Q/GettyImages-1269173310.jpg Literature - Transient Ca2+ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/11/16/the-effect-of-a-pex3-mutation-on-hearing-and-lipid-content-of-the-inner-ear monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1673970191695-WA6OR7ZNR7XEFEEXFCP0/GettyImages-1272472983.jpg Literature - The effect of a Pex3 mutation on hearing and lipid content of the inner ear. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/11/28/a-case-of-rhizomelic-chondrodysplasia-punctata-in-a-neonate monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/0181efa0-7fd9-4557-b748-4923ccb810a6/Picture1.jpg Literature - A case of Rhizomelic chondrodysplasia punctata in a neonate - Make it stand out Figure 1: Skeletal Survey: Significant shortening of humeri with mild metaphyseal flaring distally. Discrete punctate cartilaginous calcifications are present at the proximal and distal humeri. https://med-life.ca/literature/2022/11/9/research-advances-in-treatment-methods-and-drug-development-for-rare-diseases monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/4a82d53f-2218-4a96-ad6b-8e6d8dade265/Image.png Literature - Research advances in treatment methods and drug development for rare diseases. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/10/7/lipidomic-analysis-of-mussel-hemocytes-exposed-to-polystyrene-nanoplastics monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1667484095942-4MKZNB421VZEJDQWH1XV/GettyImages-1317882487.jpg Literature - Lipidomic analysis of mussel hemocytes exposed to polystyrene nanoplastics. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/10/7/plasmalogen-mediated-activation-of-gpcr21-regulates-cytolytic-activity-of-nk-cells-against-the-target-cells monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1667484187578-CU5UFYXN85W4W1GW5474/GettyImages-504877598.jpg Literature - Plasmalogen-mediated activation of GPCR21 regulates cytolytic activity of NK cells against the target cells. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/9/12/ether-lipids-transfer-across-the-blood-brain-and-placental-barriers-does-not-improve-by-inactivation-of-the-most-abundant-abc-transporters monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1665499040684-6WQ5BZFQEEA5F8W5F5RW/GettyImages-1129831675.jpg Literature - Ether lipids transfer across the blood-brain and placental barriers does not improve by inactivation of the most abundant ABC transporters. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/8/24/atp8b2-mediated-asymmetric-distribution-of-plasmalogens-regulates-plasmalogen-homeostasis-and-plays-a-role-in-intracellular-signaling-part-2 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1665498969720-5WUZRWSEPIBP6G4SJU1T/GettyImages-1181981719.jpg Literature - ATP8B2-mediated asymmetric distribution of plasmalogens regulates plasmalogen homeostasis and plays a role in intracellular signaling (Part 2) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/8/24/atp8b2-mediated-asymmetric-distribution-of-plasmalogens-regulates-plasmalogen-homeostasis-and-plays-a-role-in-intracellular-signaling-part-1 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1661980853627-7SWHN6B5YHCQRQW0LPML/GettyImages-1158006960.jpg Literature - ATP8B2-mediated asymmetric distribution of plasmalogens regulates plasmalogen homeostasis and plays a role in intracellular signaling (Part 1) - Make it stand out Representative image of a P4-ATPase. https://med-life.ca/literature/2022/9/12/shotgun-lipidomics-of-liver-and-brain-tissues-of-alzheimers-disease-model-mice-treated-with-acitretin monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1663102104553-XDGC8UUVOVVHYVL6N39H/GettyImages-622291636.jpg Literature - Shotgun lipidomics of liver and brain tissues of Alzheimer’s disease model mice treated with acitretin. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/8/24/a-pex7-deficient-mouse-series-correlates-biochemical-and-neurobehavioral-markers-to-genotype-severity-implications-for-the-disease-spectrum-of-rhizomelic-chondrodysplasia-punctata-type-1 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1661980926461-IIJWMITAHA72OP636TI1/GettyImages-1182137375.jpg Literature - A Pex7 deficient mouse series correlates biochemical and neurobehavioral markers to genotype severity – Implications for the disease spectrum of rhizomelic chondrodysplasia punctata Type 1 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/7/8/impaired-membrane-lipid-homeostasis-in-schizophrenia monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1658957207666-L9CBH6R5LVSE3CPA1YPM/GettyImages-1319031310.jpg Literature - Impaired membrane lipid homeostasis in schizophrenia. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/6/23/plasmalogens-regulate-retinal-connexin-43-expression-and-mller-glial-cells-gap-junction-intercellular-communication-and-migration monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1658957412016-OGR9225ZNSVZAPGVZDVQ/GettyImages-1317848814.jpg Literature - Plasmalogens regulate retinal connexin 43 expression and Müller glial cells gap junction intercellular communication and migration. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/6/15/plasmalogen-loss-in-sepsis-and-sars-cov-2-infection monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1655910833135-8G0F29065EEVSNTU77BV/GettyImages-1210284242.jpg Literature - Plasmalogen loss in sepsis and SARS-CoV-2 infection - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/6/3/plasmalogens-the-vinyl-ether-linked-glycerophospholipids-enhance-learning-and-memory-by-regulating-brain-derived-neurotrophic-factor monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1655910966360-KTOMF2HX9BRKWJC8DPOI/GettyImages-182433723.jpg Literature - Plasmalogens, the vinyl ether-linked glycerophospholipids, enhance learning and memory by regulating brain-derived neurotrophic factor. - Make it stand out Image of a whole mouse brain. https://med-life.ca/literature/2022/5/31/peroxisomal-stress-response-and-inter-organelle-communication-in-cellular-homeostasis-and-aging-part-2 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1655911051407-F4MF1IDW4LM03QW63XJ8/GettyImages-1301086444.jpg Literature - Peroxisomal stress response and inter-organelle communication in cellular homeostasis and aging (Part 2) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/5/31/peroxisomal-stress-response-and-inter-organelle-communication-in-cellular-homeostasis-and-aging-part-1 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1654629938873-18E24ZTTGRA5BIE6J9T6/GettyImages-1206314365.jpg Literature - Peroxisomal stress response and inter-organelle communication in cellular homeostasis and aging (Part 1) - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/4/28/time-dependent-analysis-of-plasmalogens-in-the-hippocampus-of-an-alzheimers-disease-mouse-model-a-role-of-ethanolamine-plasmalogen monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1653490110900-7ZYK00N7K5PX49WUMD22/GettyImages-1328467880.jpg Literature - Time-dependent analysis of plasmalogens in the hippocampus of an Alzheimer’s disease mouse model: A role of ethanolamine plasmalogen. - Make it stand out Neurons with accumulated beta-amyloid plaques. https://med-life.ca/literature/2022/4/13/hepatoprotective-effects-of-sea-cucumber-ether-phospholipids-against-alcohol-induced-lipid-metabolic-dysregulation-and-oxidative-stress-in-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1652196416337-NANINQ4TWXMA8UZ3932X/GettyImages-478268112.jpg Literature - Hepatoprotective effects of sea cucumber ether-phospholipids against alcohol-induced lipid metabolic dysregulation and oxidative stress in mice. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/4/13/growth-in-achondroplasia-including-stature-weight-weight-for-height-and-head-circumference-from-clarity-achondroplasia-natural-history-study monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1650992860254-XAKGMKJE4C36VR0N1EVD/GettyImages-1027723126.jpg Literature - Growth in achondroplasia including stature, weight, weight-for-height and head circumference from CLARITY: achondroplasia natural history study - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/3/18/plasmalogens-eliminate-aging-associated-synaptic-defects-and-microglia-mediated-neuroinflammation-in-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1647969364286-JHSFJMZ581Y7EV4IJV2F/GettyImages-1144879039.jpg Literature - Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice. - Make it stand out Image of ascidians, commonly called sea squirts. https://med-life.ca/literature/2022/3/18/apoe-2-resilience-for-alzheimers-disease-is-mediated-by-plasma-lipid-species-analysis-of-three-independent-cohort-studies monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/95c03300-e24a-4ffb-bf0a-df54424fcf2b/geneotyping%2Bphoto2.png Literature - 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A novel variant in the AGPS gene causes the rare rhizomelic chondrodysplasia punctata type 3: A case report. - Make it stand out Figure 1: The skeletal survey shows bilateral rhizomelic and shortening of the humeri and the femurs (A, B, C). Punctate ossification is identified at the proximal femur and distal femur and around the knees (C). Punctate ossification is noted at the proximal humeri bilaterally around the shoulder joint and along the upper spine (A, B, D, F). The vertebral bodies are not remarkable (F). The pelvis is within the normal limit (C). The head is within the normal limit (G, H). The nasogastric tube tip is seen just beyond the gastroesophageal junction (D, E). The stomach is distended (D, E). Normal cardio-mediastinal outline (E). https://med-life.ca/literature/2022/1/5/changes-in-plasma-phospholipid-metabolism-are-associated-with-clinical-manifestations-of-systemic-sclerosis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1644954750360-7L9RYJ6MBDW663X0O3CH/GettyImages-1164683998.jpg Literature - Changes in plasma phospholipid metabolism are associated with clinical manifestations of systemic sclerosis - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2022/1/5/structure-specific-accurate-quantitation-of-plasmalogen-glycerophosphoethanolamine monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1643736442990-DWKGSDM878G20MPGUD6T/GettyImages-1346396206.jpg Literature - Structure-specific, accurate quantitation of plasmalogen glycerophosphoethanolamine - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/11/25/dietary-ethanolamine-plasmalogen-alleviates-dss-induced-colitis-by-enhancing-colon-mucosa-integrity-antioxidative-stress-and-anti-inflammatory-responses monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1641931012924-IODWM415QCJ5SWKUTIO2/GettyImages-1204703694.jpg Literature - Dietary ethanolamine plasmalogen alleviates DSS-induced colitis by enhancing colon mucosa integrity, antioxidative stress, and anti-inflammatory responses - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/11/25/plasmalogen-replacement-therapy monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1641396190362-SZOD7ZGED0DWX8LUDEVO/GettyImages-1129601031.jpg Literature - Plasmalogen Replacement Therapy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/11/25/k4nfc68zhwslxdhpzkfoz5eyml0euz monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/33e0e0d4-d42a-4524-9f00-6cb57bb0908e/Picture1.png Literature - First 50 Blogs - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/11/29/neurotransmitter-release-the-last-millisecond-in-the-life-of-a-synaptic-vesicle monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1638201403839-9UNW0PXZ5QE3T49SR7WJ/GettyImages-1181363371.jpg Literature - Neurotransmitter release: The last millisecond in the life of a synaptic vesicle - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/10/20/lipid-rafts-and-neurodegeneration-structural-and-functional-roles-in-physiologic-aging-and-neurodegenerative-diseases monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1634759990175-06I9MRZI6WMHVNVTTV7B/Lipid+raft+image.jpg Literature - Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/10/20/animal-models-of-alzheimers-disease monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1635199419814-658DF31N68692ORADBAW/GettyImages-519384041.jpg Literature - Animal models of Alzheimer's disease - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/10/7/atn-an-unbiased-descriptive-classification-scheme-for-alzheimer-disease-biomarkers monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1634075509732-NWZD691ZRNZLH6AYCBQ7/GettyImages-480338933.jpg Literature - A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/10/4/a-mouse-model-system-to-study-peroxisomal-roles-in-neurodegeneration-of-peroxisome-biogenesis-disorders monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1633368055920-AAIWF9NAYBZOY1WZNDTU/IMG_9753.jpg Literature - A mouse model system to study peroxisomal roles in neurodegeneration of peroxisome biogenesis disorders - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/9/15/oral-supplementation-of-an-alkylglycerol-mix-comprising-different-alkyl-chains-effectively-modulates-multiple-endogenous-plasmalogen-species-in-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1632424560618-8YNW20CZ0B2U93FCHZ51/GettyImages-523058966.jpg Literature - Oral supplementation of an alkylglycerol mix comprising different alkyl chains effectively modulates multiple endogenous plasmalogen species in mice - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/9/15/neuroprotective-effects-of-scallop-derived-plasmalogen-in-a-mouse-model-of-ischemic-stroke monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1631743511234-RC4QAUK6Z65KQZRUE47R/GettyImages-474988990.jpg Literature - Neuroprotective effects of scallop-derived plasmalogen in a mouse model of ischemic stroke - Make it stand out CT scan of a brain after an ischemic stroke. https://med-life.ca/literature/2021/8/16/plasmalogen-attenuates-the-development-of-hepatic-steatosis-and-cognitive-deficit-through-mechanism-involving-p75ntr-inhibition monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1630447955743-7BYMKPTLA6OCMLZAVKUG/GettyImages-858263666.jpg Literature - Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition. - Make it stand out The fat accumulation in a liver with hepatic steatosis. https://med-life.ca/literature/2021/8/16/plasmalogens-regulate-the-akt-ulk1-signaling-pathway-to-control-the-position-of-the-axon-initial-segment monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1629389237536-JOQ3XPMA96A64FNOR5S1/64621224_m_parkinsons_stack_black+and+white.jpg Literature - Plasmalogens regulate the AKT-ULK1 signaling pathway to control the position of the axon initial segment. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/7/19/shark-liver-oil-supplementation-enriches-endogenous-plasmalogens-and-reduces-markers-of-dyslipidaemia-and-inflammation monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1627333704186-OPKG96P9ARTU85ZXXJ9R/unsplash-image-przZDqzZKpk.jpg Literature - Shark liver oil supplementation enriches endogenous plasmalogens and reduces markers of dyslipidaemia and inflammation - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/7/19/endothelial-ether-lipids-link-the-vasculature-to-blood-pressure-behavior-and-neurodegeneration monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1626888804092-QDZ2L308BNO8S4XZ68PQ/GettyImages-517445543.jpg Literature - Endothelial ether lipids link the vasculature to blood pressure, behavior, and neurodegeneration - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/6/23/coronavirus-induced-host-cubic-membranes-and-lipid-related-antiviral-therapies-a-focus-on-bioactive-plasmalogens monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1624465344053-XZDSU8XP4PH4W3F1C97V/unsplash-image-w9KEokhajKw.jpg Literature - Coronavirus-induced host cubic membranes and lipid-related antiviral therapies: A focus on bioactive plasmalogens - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/6/14/the-potential-role-of-bioactive-plasmalogens-in-lung-surfactant monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1623709555953-2L8I46IWVXVDMZ7B4MWH/unsplash-image-NMZdj2Zu36M.jpg Literature - The potential role of bioactive plasmalogens in lung surfactant - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/5/27/clinical-rcdp-discoveries-in-the-last-decade monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1622131275735-XAVPIOHPAGFEAF2U4SOZ/clinical+1.jpg Literature - Clinical RCDP discoveries in the last decade - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/5/17/vwbagysvb799gooktyhdjed86k6br0 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1621530985631-SNFRN9HF2R5SXQVA787B/GettyImages-1043653700.jpg Literature - The benefit of animal models in RCDP research - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/5/17/clinical-biochemical-and-molecular-characterization-of-mild-nonclassic-rhizomelic-chondrodysplasia-punctata monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1621529505239-MKG0BSGG6FI6OPXSADQZ/GettyImages-1183908006.jpg Literature - Clinical, biochemical and molecular characterization of mild (nonclassic) Rhizomelic Chondrodysplasia Punctata - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/literature/2021/5/5/a-novel-type-of-rhizomelic-chondrodysplasia-punctata-rcdp5-is-caused-by-loss-of-the-pex5-long-isoform monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1620225501844-VONU4JQI3BUJPWL83VYS/Image+Figure+2.png Literature - A novel type of rhizomelic chondrodysplasia punctata, RCDP5, is caused by loss of the PEX5 long isoform Radiographs of patient FA.II-6. (A) Radiograph of the knees at 8 months showing extensive punctate calcification (indicated by arrow). (B) Pelvis at 6 years showing narrow ilii, small and fragmented capital femoral epiphyses (indicated by arrow) with subtle calcifications. (C and D) Frontal and lateral view of the spine at 11 years showing slight s-shaped scoliosis, osteopenia and anisospondyly. https://med-life.ca/literature/2021/5/4/a-peroxisomal-disorder-of-severe-intellectual-disability-epilepsy-and-cataracts-due-to-fatty-acyl-coa-reductase-1-deficiency monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1620148205508-1BLENB310U490601I8K3/gr2.jpg Literature - A peroxisomal disorder of severe intellectual disability, epilepsy, and cataracts due to fatty acyl-CoA reductase 1 deficiency (A–D) MRI of individual II-1. Axial T2-weighted images obtained at 9 years of age (A) and again at 15 years of age (B) show increased signal intensity diffusely but more prominently in the posterior periventricular and peritrigonal regions bilaterally. There is subtle evidence of progression of these white-matter changes over time. (C) A coronal MP-RAGE-weighted image at 15 years of age shows prominence of the cerebellar folia consistent with mild to moderate cerebellar atrophy. (D) A sagittal T1-weighted image at 9 years of age shows mild atrophy of the cerebellum and no evidence of cervical spinal stenosis. https://med-life.ca/literature/2021/4/13/remodeling-of-lipid-bodies-by-docosahexaenoic-acid-in-activated-microglial-cells monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1618929736648-PZY15RGZ4HOHXO4W3KFB/GettyImages-1155196295.jpg Literature - Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells. Image of a cell containing lipid bodies. https://med-life.ca/literature/2021/3/23/anti-inflammatoryanti-amyloidogenic-effects-of-plasmalogens-in-lipopolysaccharide-induced-neuroinflammation-in-adult-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1617891645277-Q8UWCQNRL1AW9SXPLO1G/GettyImages-1155014623.jpg Literature - Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice A representation of a microglial cell and amyloid plaques within a network of neurons. https://med-life.ca/literature/2021/3/23/neuroinflammation-induced-by-lipopolysaccharide-causes-cognitive-impairment-in-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1616686986255-EKRCO3UA44NYM5QVKXDW/GettyImages-636373812.jpg Literature - Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice https://med-life.ca/literature/2021/2/17/early-disruption-of-nerve-mitochondrial-and-myelin-lipid-homeostasis-in-obesity-induced-diabetes monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1615321682190-H5FZHMJCPCIBAFJ8M8ZG/GettyImages-1212353359.jpg Literature - Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes https://med-life.ca/literature/2021/2/17/change-in-brain-plasmalogen-composition-by-exposure-to-prenatal-undernutrition-leads-to-behavioral-impairment-of-rats monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1613579786998-TV7TA3CVHOVTUM9MCSNW/black+mouse2.jpeg Literature - Change in brain plasmalogen composition by exposure to prenatal undernutrition leads to behavioral impairment of rats. https://med-life.ca/literature/2021/1/20/distinct-functions-of-acylalkyl-dihydroxyacetonephosphate-reductase-in-peroxisomes-and-endoplasmic-reticulum monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1612465315843-Q8LZ7PC9B8C3LRM7UHK5/image-asset.jpeg Literature - Distinct functions of acyl/alkyl dihydroxyacetonephosphate reductase in peroxisomes and endoplasmic reticulum https://med-life.ca/literature/2021/1/15/serum-phospholipidomics-reveals-altered-lipid-profile-and-promising-biomarkers-in-multiple-sclerosis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1611067160371-AFCGUFDRJGH5KBBWEUJ8/image-asset.jpeg Literature - Serum phospholipidomics reveals altered lipid profile and promising biomarkers in multiple sclerosis https://med-life.ca/literature/2020/11/24/how-do-ethanolamine-plasmalogens-contribute-to-order-and-structure-of-neurological-membranes monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1606229144054-U89O9XXNBZUU61A5OZA9/image-asset.jpeg Literature - How do ethanolamine plasmalogens contribute to order and structure of neurological membranes? https://med-life.ca/literature/2020/12/4/the-biophysical-properties-of-ethanolamine-plasmalogens-revealed-by-atomistic-molecular-dynamics-simulations monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1608004617098-Y18H16PZ7IVZT840NG1J/image-asset.jpeg Literature - The biophysical properties of ethanolamine plasmalogens revealed by atomistic molecular dynamics simulations Photo by vjanez/iStock / Getty Images https://med-life.ca/literature/2020/12/4/impaired-membrane-traffic-in-defective-ether-lipid-biosynthesis monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1607574345623-755ZGINJDEBF1M5N4HIZ/image-asset.jpeg Literature - Impaired membrane traffic in defective ether lipid biosynthesis Photo by selvanegra/iStock / Getty Images https://med-life.ca/literature/2020/12/2/concordant-peripheral-lipidome-signatures-in-two-large-clinical-studies-of-alzheimers-disease monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1607015287306-MC6POAIZL6PZ9C4E84WO/image-asset.jpeg Literature - Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease Photo by metamorworks/iStock / Getty Images https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1606921957393-TA9H91O37K8WVNOY6LL5/Figure+2+Image.png Literature - Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease Fig. 2 Associations of lipid class totals with prevalent and incident Alzheimer’s disease. Forest plots of lipid class associations for a prevalent Alzheimer’s disease (logistic regression, AIBL = 268 cases, 696 control, ADNI= 178 cases, 210 controls) and b incident Alzheimer’s disease (Cox regression, AIBL = 68 cases, 714 controls, ADNI= 166 cases, 397 controls). Lipid classes are generated by the sum of each individual species measured in each class. Regressions are adjusted for age, sex, BMI, total cholesterol, HDL-C, triglycerides, number of APOE4 alleles, statin use and omega-3 supplementation. AIBL was further adjusted for time points (only in logistic regression analysis) and site of blood collection. ADNI was further adjusted for fasting status. https://med-life.ca/literature/2020/11/24/plasmenylethanolamine-facilitates-rapid-membrane-fusion monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1606358327509-6FOBMFBONN2JINN4CN2G/image-asset.jpeg Literature - Plasmenylethanolamine facilitates rapid membrane fusion Photo by Rost-9D/iStock / Getty Images https://med-life.ca/literature/2020/11/10/oral-administration-of-ethanolamine-glycerophospholipid-containing-a-high-level-of-plasmalogen-improves-memory-impairment-in-amyloid-infused-rats monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1605191518812-XGHX0H6NZI43RHSBD0BP/image-asset.jpeg Literature - Oral administration of ethanolamine glycerophospholipid containing a high level of plasmalogen improves memory impairment in amyloid β-infused rats Image of sea squirts. https://med-life.ca/literature/2020/9/24/oendhb7vk45mgk6l8dg8cyc0v486kg monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1603983281737-Y77MQVTKX4U25IXZEP02/image-asset.jpeg Literature - Lipidomics unveils lipid dyshomeostasis and low circulating plasmalogens as biomarkers in a monogenic mitochondrial disorder Photo by wir0man/iStock / Getty Images https://med-life.ca/literature/2020/9/24/disturbed-neurotransmitter-homeostasis-in-ether-lipid-deficiency monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1600981397343-K4MX215J07430FZMYCOZ/1858040_m_AD_neuron_stack.jpg Literature - Disturbed neurotransmitter homeostasis in ether lipid deficiency https://med-life.ca/literature/2020/8/26/nrf2-suppresses-oxidative-stress-and-inammation-in-app-knock-in-alzheimers-disease-model-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1600189602695-QTP7LU8CC5CCMGWKGB3U/image-asset.jpeg Literature - Nrf2 suppresses oxidative stress and inflammation in App knock-in Alzheimer’s disease model mice Photo by DouglasOlivares/iStock / Getty Images https://med-life.ca/literature/2020/9/2/structural-changes-of-ethanolamine-plasmalogen-during-intestinal-absorption monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1599148220458-1CJY87U78247B6UZC1UB/image-asset.jpeg Literature - Structural changes of ethanolamine plasmalogen during intestinal absorption https://med-life.ca/literature/2020/9/3/digestion-absorption-and-metabolism-characteristics-of-epa-enriched-phosphoethanolamine-plasmalogens-based-on-gastrointestinal-functions-in-healthy-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1599143406865-X1WMHTIIT79Z5AF2QW55/image-asset.jpeg Literature - Digestion, absorption, and metabolism characteristics of EPA-enriched phosphoethanolamine plasmalogens based on gastrointestinal functions in healthy mice https://med-life.ca/literature/2020/7/28/locations-and-contributions-of-the-phosphotransferases-ept1-and-cept1-to-the-biosynthesis-of-ethanolamine-phospholipids monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1597776176795-15T1IPHVZ3AI1XV07AMU/image-asset.jpeg Literature - Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids Photo by Rasi Bhadramani/iStock / Getty Images https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1595975296111-I8WY5P318CY08YD2BSRV/Figure+2.png Literature - Locations and contributions of the phosphotransferases EPT1 and CEPT1 to the biosynthesis of ethanolamine phospholipids Figure 2: Immunocytochemistry of EPT1 and CEPT1 in HEK293 cells. HEK293 cells were transfected with the expression vector for CEPT1 (A) or EPT1 (B) tagged with HA at the C-terminus. After fixation, the cells were permeabilized with 0.1% Triton X-100 (w/v), then immunostained with anti-HA antibody, followed by anti-mouse IgG Alexa488 (green). The ER and Golgi apparatus were stained with anti-ERp72 and GM130 antibodies, respectively, followed by anti-rabbit IgG Alexa594 (red). Nuclei were stained with DAPI (blue). Bars indicate 10uM https://med-life.ca/literature/2020/6/30/oral-batyl-alcohol-supplementation-rescues-decreased-cardiac-conduction-in-ether-phospholipid-deficient-mice monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1595445122572-OIDX92KK7PMOL7PQQAIR/image-asset.jpeg Literature - Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid-deficient mice. Photo by yodiyim/iStock / Getty Images https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1593535766734-JJCDC1613TMSBODHMW1M/bg4.png Literature - Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid-deficient mice. Original ECG recording from a WT (blue; upper trace) and a Gnpat KO mouse before treatment with BA (red, middle trace) and after treatment with BA (green, lower trace). The traces (lead I) are aligned with respect to the start of the QRS complex. With reference to the trace in the upper panel (blue), the solid vertical lines indicate, from left to right, the beginning of the P-wave and the beginning and the end of the QRS complex. Furthermore, the peak of the first T-wave (dotted line) and the end of the second T- wave (right) in the upper trace (WT) are indicated. The arrows indicate the end of the QRS complex in the middle trace (Gnpat KO at baseline, red) and the lower trace (Gnpat KO after BA, green). Clearly, the duration of the QRS interval and the QT1 interval are prolonged in the Gnpat KO mouse. However, treatment with BA in this mouse results in normalization of the QRS duration. https://med-life.ca/literature/2020/6/17/the-tmem189-gene-encodes-plasmanylehtanolamine-desaturase-which-introduces-the-characterisitic-vinyl-ether-double-bond-into-plasmalogens monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1595513971799-DC60C0Z2TGFDZK6F39AD/Plasmalogen.png Literature - The TMEM189 gene encodes plasmanylehtanolamine desaturase which introduces the characterisitic vinyl ether double bond into plasmalogens https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1592412337729-VFK9O7XX1HSYWOKSMLXM/image-asset.jpeg Literature - The TMEM189 gene encodes plasmanylehtanolamine desaturase which introduces the characterisitic vinyl ether double bond into plasmalogens Fig. 1. PEDS gene identification. (G) PEDS activities in WT HAP1 cells compared with TMEM189-deficient HAP1 cells (ΔTMEM189) at 48 h posttransfection with expression plasmids for GFP, for selected desaturase and hydroxylase proteins, and for TMEM189 protein. Data are mean ± SEM for three independent experiments. (H) Plasmalogen content of WT HAP1 cells compared with TMEM189-deficient HAP1 cells. Data are mean ± SEM for three independent experiments. https://med-life.ca/literature/2020/6/15/association-of-cholesterol-efflux-capacity-with-plasmalogen-levels-of-high-density-lipoprotein-a-cross-sectional-study-in-chronic-kidney-disease-patients-1 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1593035099552-BA7R8160WZ81VC7L0UIS/image-asset.jpeg Literature - Association of cholesterol efflux capacity with plasmalogen levels of high-density lipoprotein: A cross-sectional study in chronic kidney disease patients Photo by Christoph Burgstedt/iStock / Getty Images https://med-life.ca/literature/2020/5/26/-synuclein-dimerization-in-erythrocytes-of-gaucher-disease-patients-correlation-with-lipid-abnormalities-and-oxidative-stress monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1592341082186-U8Z8Y0VFDI2TV5UAELMR/image-asset.jpeg Literature - α-synuclein dimerization in erythrocytes of Gaucher disease patients: correlation with lipid abnormalities and oxidative stress. https://med-life.ca/literature/2020/5/26/reduced-muscle-strength-in-ether-lipid-deficient-mice-is-accompanied-by-altered-development-and-function-of-the-neuromuscular-junction monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1590512391547-M73QHZ5ZUKHTFOWD0A0L/acetylcholine+clusters+figure+-+Copy.jpg Literature - Reduced muscle strength in ether lipid-deficient mice is accompanied by altered development and function of the neuromuscular junction Impaired acetylcholine receptor (AChR) clustering in vitro in Gnpat KO myotubes. Clustering of AChRs was induced by stimulation with neural agrin in myotubes derived from immortalized myoblasts from WT and Gnpat KO mice. AChRs were stained with Alexa Fluor 594-conjugated α-BTX and representative images of clusters (indicated by arrows) are shown in (a) for both genotypes; scale bar: 10 um. Quantifications of cluster number. https://med-life.ca/literature/2020/5/11/epa-enriched-ethanolamine-plasmalogen-and-epa-enriched-phospatidylethanolamine-enhance-bdnftrkbcreb-signaling-and-inhibit-neuronal-apoptosis-in-vitro-and-in-vivo monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1590437251852-KXA9S59JS7D2K4GFHR8P/image-asset.jpeg Literature - EPA-enriched ethanolamine plasmalogen and EPA-enriched phospatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo https://med-life.ca/literature/2020/5/5/a-comparative-study-of-epa-enriched-ethanolamine-plasmalogen-and-epa-enriched-phosphatidylethanolamine-on-a42-induced-cognitive-deficiency-in-a-rat-model-of-alzheimers-disease monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1589317356190-DIEPLL09DDTGOPEJQ2TQ/14564048_ml_MRI.jpg Literature - A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Aβ42 induced cognitive deficiency in a rat model of Alzheimer’s disease https://med-life.ca/literature/2020/4/20/promotion-of-plasmalogen-biosynthesis-reverse-lipid-changes-in-a-barth-syndrome-cell-model monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1588103602403-FVXF3QRCZW94AV4GTTXQ/image-asset.jpeg Literature - Promotion of plasmalogen biosynthesis reverse lipid changes in a Barth Syndrome cell model https://med-life.ca/literature/2020/4/2/leukodystrophy-caused-by-plasmalogen-deficiency-rescued-by-glyceryl-1-myristyl-ether-treatment monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1586972537701-MZCH74ANMIN94O0BSQZF/52078159_m_MS_neuron_stack.jpg Literature - Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment https://med-life.ca/literature/2020/3/27/regulation-of-phagocytosis-in-macrophages-by-membrane-ethanolamine-plasmalogens monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1585799574843-365C00UUYPUFC3340E2R/image-asset.jpeg Literature - Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens Photo by Dr_Microbe/iStock / Getty Images https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1585329513534-LI6KVHAP3OAA9FAY0068/image-asset.jpeg Literature - Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens Effect of lysoPlsEtn on the phagocytosis of different targets by RAW 264.7 and plasmalogen-deficient RAW.108 cells. The cells were either untreated or treated with 10 µM lysoPlsEtn or 10 µM lysoPtdEtn for 10 min as indicated. Afterward, unopsonized latex beads (5–7 particles/cell, 30-min incubation) or apoptotic Jurkat cells (ratio 3:1, 2-h incubation) were added, and phagocytosis was analyzed by flow cytometry. Measurements run in parallel using opsonized zymosan particles (OpZ, 5–7 particles/cell) are also shown for direct comparison. *Significantly different (p < 0.05) from untreated cells; **significantly different (p < 0.01) from untreated cells. https://med-life.ca/literature/2020/3/20/a-caenorhabditis-elegans-model-for-ether-lipid-biosynthesis-and-function monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1585799682311-0SRBQDCIYSLNC0CKNVOH/image-asset.jpeg Literature - A Caenorhabditis elegans model for ether lipid biosynthesis and function Photo by HeitiPaves/iStock / Getty Images https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1584732551957-4SMYL7N1RODR29S30ZKV/Worm_data.jpg Literature - A Caenorhabditis elegans model for ether lipid biosynthesis and function Physiological consequences of ether lipid deficiency. A: Ether lipid-deficient mutants show reduced survival when grown at 15 C, and fail to survive at 10 C. Two-tailed t-tests were used to determine the significance between the mean cold survival of each mutant strain compared with wild-type at the same temperature. * P<0.05, P<0.001. B: Ether-lipid deficient mutants have a reduced number of viable progeny at 20 C. Graphs show the range and average number of progeny in eight to ten individuals of each genotype. The brood size of each mutant is significantly different from wild-type, ** P<0.0001 as determined by one-way ANOVA and Dunnett’s multiple comparison test. C: Lifespan of ether-lipid deficient at 20 C is shorter than wild-type, P<0.0001 as determined by log-rank (Cox-Mantel) test. D, E: Ether-lipid deficient mutants show reduced survival in the presence of acute oxidative stress. For both oxidants, P<0.001 as determined by log-rank (Cox-Mantel) test. F: Ether lipid-deficient mutants are not more sensitive to ER stress than wild-type. https://med-life.ca/literature/2020/3/20/rhizomelic-chondrodysplasia-punctate-morbidity-and-mortality-an-update monthly 0.5 2025-08-13 https://med-life.ca/news1 daily 0.75 2025-10-20 https://med-life.ca/news1/2025/10/20/mld-presenting-at-world-orphan-drug-congress-in-amsterdam monthly 0.5 2025-10-20 https://med-life.ca/news1/2025/6/23/rhizokids-2025 monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/82b41c80-f092-4bdf-9d84-e8a5bb5726bc/Rhizokids+2025.png News - RhizoKids 2025 - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://med-life.ca/news1/2025/4/10/mld-is-tackling-your-most-asked-questions monthly 0.5 2025-08-13 https://med-life.ca/news1/2025/3/18/mld-announces-publication-of-rhizoqol-survey monthly 0.5 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1742317593043-PEJTUQ1VTFWXAM2LVVBV/unsplash-image-Hcfwew744z4.jpg News - 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CEO and Chief Scientific Officer https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1569281176999-4BBMW4JQ0VQPEDMMQP81/tara_pic_webpage.jpg Corporate https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571853702744-NN487V05CMHP8TF4J8WB/IMG_4552.jpg Corporate https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1569281202178-HP7RYLCH0XSMOWE0H4RM/Shawn_casual_profile_pic.jpg Corporate Shawn Ritchie, PhD. CEO and Chief Scientific Officer https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1569281176999-4BBMW4JQ0VQPEDMMQP81/tara_pic_webpage.jpg Corporate https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571853702744-NN487V05CMHP8TF4J8WB/IMG_4552.jpg Corporate https://med-life.ca/rcdp daily 0.75 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1568149256061-NTCQ3XM0XE778AXQ802G/Jackson1_original.JPG RCDP https://med-life.ca/plasmalogens daily 0.75 2025-08-13 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1569443786335-EIX6FD9Q6XP6Y52MD34D/lipidmembrane_purple.jpg Plasmalogens https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1568147398588-4BIVFLNYXL2QMAVVN8VP/PlsEtn_structure.png Plasmalogens A neuronal cell is shown on the left. The membrane surface of the cell is composed of the lipid membrane bilayer, which contains two rows of lipid molecules packed closely together. This layer essentially acts as a barrier, controlling what enters and leaves the cell. It also serves as the location for which many cell surface proteins, such as receptors, are anchored. Such cell surface proteins are involved in cell-cell communication, activation of signalling pathways involved in various cellular functions, and more. There are multiple types of phospholipids that make up the cell membrane. Plasmalogens represent one class of lipids, as shown above, that contain the vinyl-ether bond (red box). In contrast, a conventional phospholipid contains two acyl bonds, as shown in the black box. In some cell types, such as neurons, over 50% of the cell membrane can be comprised of plasmalogens. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571867575701-8T4XPDC14NWCN13VLKC9/Px+Overview.jpg Plasmalogens Peroxisomes are tiny organelles in a cell that carry out specific metabolic functions, including the first steps of plasmalogen biosynthesis. The therapeutic approach at MLD is to bypass plasmalogen biosynthetic enzymes with plasmalogen precursors. PPI-1011 is an ether-containing precursor that a human adult can metabolically convert into a vinyl-ether plasmalogen that is then used by the body to augment the entire endogenous plasmalogen pool, while PPI-1040, designed exclusively for Rhizomelic Chondrodysplasia Punctata (RCDP) contains a fully intact and stabilized vinyl-ether bond that requires NO metabolic conversion by the body into an endogenous plasmalogen species. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1568147398588-4BIVFLNYXL2QMAVVN8VP/PlsEtn_structure.png Plasmalogens A neuronal cell is shown on the left. The membrane surface of the cell is composed of the lipid membrane bilayer, which contains two rows of lipid molecules packed closely together. This layer essentially acts as a barrier, controlling what enters and leaves the cell. It also serves as the location for which many cell surface proteins, such as receptors, are anchored. Such cell surface proteins are involved in cell-cell communication, activation of signalling pathways involved in various cellular functions, and more. There are multiple types of phospholipids that make up the cell membrane. Plasmalogens represent one class of lipids, as shown above, that contain the vinyl-ether bond (red box). In contrast, a conventional phospholipid contains two acyl bonds, as shown in the black box. In some cell types, such as neurons, over 50% of the cell membrane can be comprised of plasmalogens. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571867575701-8T4XPDC14NWCN13VLKC9/Px+Overview.jpg Plasmalogens Peroxisomes are tiny organelles in a cell that carry out specific metabolic functions, including the first steps of plasmalogen biosynthesis. The therapeutic approach at MLD is to bypass plasmalogen biosynthetic enzymes with plasmalogen precursors. PPI-1011 is an ether-containing precursor that a human adult can metabolically convert into a vinyl-ether plasmalogen that is then used by the body to augment the entire endogenous plasmalogen pool, while PPI-1040, designed exclusively for Rhizomelic Chondrodysplasia Punctata (RCDP) contains a fully intact and stabilized vinyl-ether bond that requires NO metabolic conversion by the body into an endogenous plasmalogen species. https://med-life.ca/alzheimers daily 0.75 2019-12-12 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1567039015351-3IXGWBY943FVB8NY6WHH/52776814_ml_AD_caregiver.jpg Alzheimer's https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1570299680026-F7RKNZYTGJRD047ODFDT/AD+model.jpg Alzheimer's Plasmalogens are naturally produced by the body and reach peak levels early in life. As the body ages, plasmalogen levels decline in at least a subset of the population. This is likely the result of age-related decline in peroxisomal output, the subcellular organelle where plasmalogen biosynthetic enzymes are located. Other factors, such as accumulating inflammation, environmental factors, diet, and exercise are also known risk factors for dementia and likely interact with plasmalogen deficiency in driving disease progression. At some point, plasmalogen levels decline to a point that cell membrane structure is sufficiently compromised resulting in impaired vesicular fusion and neurotransmitter release. Eventually this leads to early-stage memory loss and ultimately onset of dementia. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1570299680026-F7RKNZYTGJRD047ODFDT/AD+model.jpg Alzheimer's Plasmalogens are naturally produced by the body and reach peak levels early in life. As the body ages, plasmalogen levels decline in at least a subset of the population. This is likely the result of age-related decline in peroxisomal output, the subcellular organelle where plasmalogen biosynthetic enzymes are located. Other factors, such as accumulating inflammation, environmental factors, diet, and exercise are also known risk factors for dementia and likely interact with plasmalogen deficiency in driving disease progression. At some point, plasmalogen levels decline to a point that cell membrane structure is sufficiently compromised resulting in impaired vesicular fusion and neurotransmitter release. Eventually this leads to early-stage memory loss and ultimately onset of dementia. https://med-life.ca/parkinsons daily 0.75 2019-10-25 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1567039232380-XUFARLSJ06TAJRPSP10E/41664069_ml_walker%2Bcopy.jpg Parkinson's https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571418563013-SXBAD3YA8JRJRYV56N3Y/LDOPA+DYS.png Parkinson's For more references relating to PPI-1011 efficacy in Parkinson’s disease, see our other publications: Behavioural Brain Research 337 (2018) 183–185, Behavioural Brain Research 286 (2015) 328–337, Brain Research 1674 (2017) 70–76, PLOS ONE | DOI:10.1371/journal.pone.0151020 March 9, 2016, Brain Research 1725 (2019) 146460, https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571418563013-SXBAD3YA8JRJRYV56N3Y/LDOPA+DYS.png Parkinson's For more references relating to PPI-1011 efficacy in Parkinson’s disease, see our other publications: Behavioural Brain Research 337 (2018) 183–185, Behavioural Brain Research 286 (2015) 328–337, Brain Research 1674 (2017) 70–76, PLOS ONE | DOI:10.1371/journal.pone.0151020 March 9, 2016, Brain Research 1725 (2019) 146460, https://med-life.ca/multiple-sclerosis daily 0.75 2019-10-25 https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1567039555064-M619BXJ9VJKCD0JC9WWD/14564048_ml_MRI.jpg Multiple Sclerosis https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571419895896-79TDWBZK5US8G9VNMX8V/MS+myelin.jpg Multiple Sclerosis Plasmalogen treatment protects against demyelination as shown by histopathology of the corpus callosum (see arrow) in control, cuprizone and cuprizone+plasmalogen treated mice. Unpublished results. https://images.squarespace-cdn.com/content/v1/5b8f64064611a0621c0b53e1/1571419895896-79TDWBZK5US8G9VNMX8V/MS+myelin.jpg Multiple Sclerosis Plasmalogen treatment protects against demyelination as shown by histopathology of the corpus callosum (see arrow) in control, cuprizone and cuprizone+plasmalogen treated mice. Unpublished results. https://med-life.ca/legal daily 0.75 2019-10-23 https://med-life.ca/order-form daily 0.75 2019-10-24 https://med-life.ca/intellectual-property daily 0.75 2019-11-01 https://med-life.ca/home daily 1.0 2025-12-14 https://med-life.ca/our-partners daily 0.75 2025-08-13 https://images.squarespace-cdn.com/content/v1/59dbc7c2cf81e0c47e15482d/1508275125376-JS5UW5HKEMC9UK5ZOE9H/Untitled-7.jpg Our Partners - Our Partners (Copy) Our Partners Here is a description of your partners. Lorem ipsum dolor sit amet, consectetur adipiscing elit. Fusce mattis turpis vel ex semper. 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